Recombinant Antigen Proteins
Recombinant antigen proteins serve as core functional raw materials for tumor immunology, cell therapy, antibody drug development, and the study of immunological mechanisms. They span four major research application areas: immune checkpoint targets, CAR-T therapy targets, CD differentiation antigens, and Fc receptors. These proteins precisely correspond to key physiological and pathological processes—such as immune activation, immune escape, antigen recognition, and antibody binding—making them essential reagents for academic immunology research, innovative drug screening, cell therapy process development, and *in vitro* functional validation. Our entire range of recombinant antigen proteins is produced using established eukaryotic expression systems, ensuring the full preservation of natural extracellular domains; they exhibit high activity, strong specificity, and consistent purity. Available in both human and murine forms, they fully meet the experimental requirements across the entire spectrum of basic research and drug development.
All products undergo rigorous purification, endotoxin removal, and sterility quality control, ensuring minimal batch-to-batch variation. They are suitable for applications such as protein binding assays, antibody affinity validation, CAR-T cell functional assays, and the study of immune signaling pathways. Comprehensive Certificates of Analysis (COA) and Material Safety Data Sheets (MSDS) are provided for every batch. We support immediate delivery, small-scale sampling, and long-term bulk procurement, catering to the routine R&D needs of academic institutions and biopharmaceutical companies.
Product Features
- Native, Intact Conformation with Superior Binding Activity：Produced and purified using the HEK293 eukaryotic expression system, the antigen retains its native extracellular spatial conformation and key binding sites, faithfully replicating in vivo protein functionality. It demonstrates stable antigen-antibody and receptor-ligand binding activity, ensuring high experimental reproducibility.
- Comprehensive Coverage Across All Target Categories：Integrates five core categories—immune checkpoints, popular CAR-T targets, immune co-stimulatory molecules, pattern recognition receptors, and Fc receptors—covering key research targets across the fields of tumor immunology, cell therapy, inflammatory immunology, and antibody drug development.
- Dual-Species Compatibility for Diverse Experimental Systems：Offers corresponding target proteins for both human and mouse species, ensuring seamless compatibility between human cell-based assays and mouse model control experiments, thereby meeting multifaceted needs ranging from mechanistic validation in basic research to drug efficacy evaluation.
- High Purity, Low Endotoxin: Setting a Higher Standard：Processed via a refined workflow involving multi-stage affinity purification, sterilization, and endotoxin removal, the protein exhibits high purity and negligible residual impurity proteins. Free from endotoxin interference, it is suitable for high-standard applications such as cell viability assays, in vivo studies, and drug development testing.
- Batch-to-Batch Consistency: Ideal for Long-Term R&D：Utilizing a standardized mass-production quality control system, we strictly monitor key parameters—including protein activity, concentration, purity, and stability—to ensure minimal batch-to-batch variation. This reliability supports long-term academic research, iterative new drug development by pharmaceutical companies, and large-scale, repetitive experiments.
- Compliant Quality Control with Full Traceability：Each product batch comes with a Certificate of Analysis (COA) and a Material Safety Data Sheet (MSDS). Our standardized quality control processes and complete certifications ensure compliance with the usage and project acceptance standards of research institutions and biopharmaceutical companies.
- Ready-to-Use Design for Research Efficiency：Products undergo purification, buffer exchange, and sterilization, eliminating the need for complex pre-treatment. They are ready for immediate use in applications such as ELISA coating, flow cytometry, antibody screening, and cell function assays, significantly shortening experimental preparation time.
Product List
| Product Catalog No. | Product Name | Size | Application Scenarios |
|---|---|---|---|
| JLP4001 | Human PD‑L1 Protein | 10 μg/50 μg/100 μg, sterile lyophilized powder | Immune checkpoint inhibitor screening, tumor immune escape mechanism research, antibody binding assays |
| JLP4002 | Human CD40L Protein | 10 μg/50 μg/100 μg, sterile lyophilized powder | Immune co‑stimulatory pathway research, inflammation model establishment, immune activation mechanism experiments |
| JLP4003 | Human CD47 Protein | 10 μg/50 μg/100 μg, sterile lyophilized powder | Tumor phagocytosis escape research, targeted antibody screening, immune escape mechanism research |
| JLP4004 | Human CTLA‑4 Protein | 10 μg/50 μg/100 μg, sterile lyophilized powder | T‑cell immunosuppression research, immune checkpoint drug development, target binding validation |
| JLP4100 | Human B7‑H3 Protein | 10 μg/50 μg/100 μg, sterile lyophilized powder | CAR‑T target validation, tumor immunosuppression research, novel antibody drug screening |
| JLP4101 | Human CD4 Protein | 10 μg/50 μg/100 μg, sterile lyophilized powder | CAR‑T cell function validation, immune cell phenotyping research, target binding assays |
| JLP4102 | Human CD19 Protein | 10 μg/50 μg/100 μg, sterile lyophilized powder | CD19‑CAR‑T development and validation, lymphoma immunology research, targeted drug screening |
| JLP4200 | Human ICOS Protein | 10 μg/50 μg/100 μg, sterile lyophilized powder | T‑cell activation studies, autoimmune disease models, co‑stimulatory pathway mechanism studies |
| JLP4201 | Human TLR2 Protein | 10 μg/50 μg/100 μg, sterile lyophilized powder | Innate immune recognition, inflammatory response mechanisms, pathogen infection‑related research |
| JLP4202 | Mouse TLR2 Protein | 10 μg/50 μg/100 μg, sterile lyophilized powder | Mouse inflammatory animal models, in vivo immune mechanism validation experiments |
| JLP4203 | Human TLR4 Protein | 10 μg/50 μg/100 μg, sterile lyophilized powder | Inflammatory pathway studies, endotoxin response, screening for innate immune‑targeted drugs |
| JLP4300 | Human CD16 Protein | 10 μg/50 μg/100 μg, sterile lyophilized powder | ADCC effect assays, antibody Fc‑region binding validation, immune effector function studies |
| JLP4301 | Human CD64 Protein | 10 μg/50 μg/100 μg, sterile lyophilized powder | Antibody affinity assays, Fc receptor functional studies, efficacy evaluation of antibody drugs |
Main Application Scenarios
- Tumor Immunology Research: Utilizing immune checkpoint proteins such as PD-L1, CTLA-4, CD47, and B7-H3 to study mechanisms of tumor immune escape, T-cell activation inhibition, and immune regulation within the tumor microenvironment; suitable for basic tumor research and the investigation of pathogenesis.
- CAR-T Cell Therapy R&D and Validation: Key target proteins such as CD19, CD4, and B7-H3 facilitate the validation of CAR-T cell target-binding specificity, positive rate detection, and *in vitro* functional activity assessment, supporting process development and performance validation for cell therapy drugs.
- Antibody Drug Screening and Efficacy Evaluation: Suitable for *in vitro* target binding assays, affinity screening, activity verification, and efficacy evaluation of monoclonal antibodies, bispecific antibodies, ADCs, and immune checkpoint inhibitors, covering the entire early-stage drug development process.
- Inflammation and Innate Immunity Research: Proteins such as TLR2, TLR4, ICOS, and CD40L enable the study of inflammatory responses, innate immune recognition, and T-cell co-stimulatory signaling pathways; suitable for research on inflammatory diseases and immune disorders.
- Fc Receptor Function and Antibody Effector Studies: Fc receptor proteins such as CD16 and CD64 are used to validate antibody Fc-region binding characteristics, detect antibody-dependent cellular cytotoxicity (ADCC), and evaluate antibody drug functionality—serving as core materials for optimizing antibody efficacy.
- Multi-species Model Comparative Studies: Leveraging dual-species protein systems (human and murine) to enable integrated validation between *in vitro* cell assays and *in vivo* animal models, meeting the needs for in-depth research, data comparison, and iterative development of findings.
Storage and Quality Control Standards
Storage Conditions：Lyophilized powder stored at -20°C away from light, do not repeatedly freeze-thaw. After reconstitution, aliquot and store short-term at 4°C, long-term at -80°C.
Shelf Life：Unopened lyophilized powder shelf life is 24 months. Best used within 1 month after reconstitution.
