Chemokines
Chemokine Receptors are a class of G protein-coupled receptors (GPCRs) that mediate critical processes such as cell migration, chemotaxis, immune infiltration, and signal regulation. They serve as pivotal targets in research areas including inflammatory immunity, the tumor microenvironment, pathogen infection, and autoimmune diseases. Involved in a wide range of physiological and pathological processes—such as leukocyte recruitment, immune cell localization, tissue inflammation and repair, and tumor invasion and metastasis—these receptors provide essential materials for immunological mechanism studies, targeted drug development, and the establishment of inflammation models.Our comprehensive portfolio of recombinant chemokine receptors covers the most popular subtypes within the CC and CXCR families across both human and murine species. Produced using eukaryotic expression systems, these proteins feature native structures, stable activity, and high specificity, making them ideally suited for basic research and drug screening in university laboratories, biopharmaceutical companies, and innovative drug developers.
Our entire product line undergoes rigorous purification and quality control to ensure freedom from contaminating proteins and minimal batch-to-batch variation. Each batch is accompanied by a Certificate of Analysis (COA) and a Material Safety Data Sheet (MSDS). We offer both immediate stock availability and long-term bulk procurement options, reliably meeting the needs of diverse research applications, including *in vitro* binding assays, receptor-ligand validation, cell chemotaxis assays, and target-specific antibody screening.
Product Features
- Native protein conformation with high specificity：Produced and purified using the HEK293 eukaryotic expression system, the proteins fully retain their native transmembrane structures and extracellular ligand‑binding domains. With intact receptor activity, they bind precisely to their corresponding chemokine ligands while exhibiting minimal non‑specific binding, ensuring accurate and reliable experimental data.
- Broad Species Coverage and Versatility：Covers key chemokine receptor subtypes from both human and mouse sources. Perfectly suited for studying human disease mechanisms, validating mouse animal models, and conducting cross‑species comparative studies, thereby meeting diverse research needs.
- Consistent Batch Quality and Excellent Reproducibility：Manufactured using standardized industrial processes with strict controls on key parameters—such as purity, activity, concentration, and stability—to minimize batch‑to‑batch variation. Ideal for long‑term research projects, large‑scale repetitive experiments, and pharmaceutical R&D.
- Comprehensive Coverage of Popular Targets：Includes major research targets in tumor immunology, inflammatory diseases, and viral infections—such as CCR2/4/5/8/9 and CXCR2/3—aligning with current trends in immunology, oncology, and anti‑inflammatory drug development.
- Compliant Quality Control and Full Traceability：Every batch undergoes rigorous quality testing; complete Certificates of Analysis (COA) and Material Safety Data Sheets (MSDS) are provided. Fully certified and compliant with regulatory standards for use in university laboratories and biopharmaceutical R&D.
- Ready‑to‑Use Design for Experimental Efficiency：Products are pre‑purified, sterilized, and optimized for stability. Requiring no complex pre‑treatment, they can be used immediately in applications such as protein‑protein interaction studies, in vitro binding assays, cell chemotaxis assays, and antibody screening, significantly reducing experiment preparation time.
Product List
| Product Catalog No. | Product Name | Size | Application Scenarios |
|---|---|---|---|
| JLP3100 | Mouse CCR2 Protein | 10 μg / 50 μg / 100 μg, sterile lyophilized powder | Mouse inflammation models, immune infiltration, tumor metastasis mechanism research |
| JLP3101 | Human CCR4 Protein | 10 μg / 50 μg / 100 μg, sterile lyophilized powder | Autoimmune disease research, tumor immune escape, target drug screening |
| JLP3102 | Human CCR5 Protein | 10 μg / 50 μg / 100 μg, sterile lyophilized powder | Viral infection mechanisms, inflammatory immunity, anti‑tumor targeted drug R&D |
| JLP3103 | Human CCR8 Protein | 10 μg / 50 μg / 100 μg, sterile lyophilized powder | Tumor microenvironment regulation, skin inflammation, immune cell migration research |
| JLP3104 | Human CCR9 Protein | 10 μg / 50 μg / 100 μg, sterile lyophilized powder | Gut immunity research, mucosal inflammation, immune target mechanism experiments |
| JLP3105 | Human CXCR2 Protein | 10 μg / 50 μg / 100 μg, sterile lyophilized powder | Inflammatory chemotaxis, tumor angiogenesis, cell migration experimental studies |
| JLP3106 | Mouse CXCR2 Protein | 10 μg / 50 μg / 100 μg, sterile lyophilized powder | In‑vivo mouse inflammation models, tumor metastasis control verification experiments |
| JLP3107 | Human CXCR3 Protein | 10 μg / 50 μg / 100 μg, sterile lyophilized powder | Immune cell activation, inflammatory response, tumor immune regulation research |
Main Application Scenarios
- Research on Inflammation and Immune Mechanisms: Used to study fundamental mechanisms such as inflammatory responses, immune cell chemotaxis and migration, lymphocyte infiltration, and mucosal immune regulation; suitable for experiments related to autoimmune diseases, chronic inflammation, and allergic disorders.
- Research on Tumor Immunology and Metastasis: Supports studies on the regulation of the tumor microenvironment, tumor cell invasion and metastasis, and mechanisms of immune escape, providing core materials for the development of research models for cancers such as breast cancer, lung cancer, and gastrointestinal tumors.
- Targeted Drug R&D and Screening: Suitable for the in vitro target validation, activity screening, and ligand-receptor interaction assays of chemokine receptor-targeting antibody drugs, small-molecule inhibitors, and anti-inflammatory drugs, supporting the early-stage development of new drugs.
- Research on Viral Infection Mechanisms: Suitable for studying receptor-mediated viral entry mechanisms (such as those involving CCR5) and applicable to research areas including viral infection, host immune responses, and antiviral target screening.
- Animal models and control experiments: Relying on human + mouse dual-species products, it is possible to connect and verify in vitro cell experiments and mouse in vivo model experiments to meet the needs of in-depth research and data comparison of the subject.
- Applications in Cell Function Assays: Supports immune cell chemotaxis assays, cell activation and migration assays, and the construction of in vitro inflammation models; widely suitable for routine research and R&D in universities and pharmaceutical companies.
Storage and Quality Control Standards
Storage Conditions：Lyophilized powder stored at -20°C away from light, avoid repeated freeze-thaw cycles. After reconstitution, aliquot and store short-term at 4°C, long-term at -80°C.
Shelf Life：Unopened lyophilized powder shelf life is 24 months. After reconstitution, recommend using within 1 month to ensure stable chemotactic activity.
